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Rabbit Polyclonal Antibody to p53 (Phospho-Ser392)

Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-p53 (Ser392) antibody P40603.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to p53 (Phospho-Ser392)

货号：
P40603
别名：
Antigen NY-CO-13; Cellular tumor antigen p53; Phosphoprotein p53; TP53; Tumor suppressor p53
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P04637
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to p53 (Phospho-Ser392)

Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.Choi DW, et al. (2013) Mol Cell 51, 374-85 Bagashev A, et al. (2013) Cell Cycle 12, 1569-77 Shahar OD, et al. (2013) PLoS One 8, e78472

Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.Choi DW, et al. (2013) Mol Cell 51, 374-85 Bagashev A, et al. (2013) Cell Cycle 12, 1569-77 Shahar OD, et al. (2013) PLoS One 8, e78472

Specification
Aliases	Antigen NY-CO-13; Cellular tumor antigen p53; Phosphoprotein p53; TP53; Tumor suppressor p53
Entrez GeneID	7157;
Swissprot	P04637
WB Predicted band size	53kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine 392 (P-D-S(p)-D) derived from Human p53.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.