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Western blot analysis using AURKB mouse mAb against F9 (1), COS7 (2), and C2C12 (3) cell lysate.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using AURKB mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using AURKB mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using AURKB mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded rat thymus tissues using AURKB mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded rabbit thymus tissues using AURKB mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded mouse spleen tissues using AURKB mouse mAb with DAB staining.
HOT

Mouse Monoclonal Antibody to AURKB

  • 货号:

    20115
  • 别名:

    AURKB
  • 产品上架时间:

    2024-03-03
  • 应用:

    WB,IF
  • 反应种属:

    Human, Rat, Mouse, Monkey, Rabbit
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q96GD4
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to AURKB

Description

AURKB (aurora kinase B, AIK2 or aurora-B), with 344-amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis.It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases

References

1. Song J et al. Immunity 22:621-31 (2005).
2. Kapoor P et al. Mol Cell Biol 25:4934-45 (2005).

Specification

Aliases AURKB
Entrez GeneID 9212
Swissprot Q96GD4
clone 13E8D3
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Rat, Mouse, Monkey, Rabbit
Immunogen Purified recombinant fragment of AURKB expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
ELISA 1/10000