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Rabbit Polyclonal Antibody to PDCD4 (Phospho-Ser457)

Western blot analysis of extracts from 293 cells treated with Serum using Phospho-PDCD4 (Ser457) antibody P40597.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to PDCD4 (Phospho-Ser457)

货号：
P40597
别名：
neoplastic transformation inhibitor;
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q53EL6
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to PDCD4 (Phospho-Ser457)

Description
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNAKakade D, Islam N, Maeda N, Adegoke OA (2014) BMC Cell Biol 15, 2. Wippich F, et al. (2013)Cell 152, 791-805 . LaRonde-LeBlanc N, et al. (2007)Mol Cell Biol 27, 147-56.

Description

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNAKakade D, Islam N, Maeda N, Adegoke OA (2014) BMC Cell Biol 15, 2. Wippich F, et al. (2013)Cell 152, 791-805 . LaRonde-LeBlanc N, et al. (2007)Mol Cell Biol 27, 147-56.

Specification
Aliases	neoplastic transformation inhibitor;
Entrez GeneID	27250;
Swissprot	Q53EL6
WB Predicted band size	51kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of serine 457 (F-V-S(p)-E-G) derived from Human PDCD4 .
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.