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Rabbit Polyclonal Antibody to CBL (Phospho-Tyr674)

Western blot analysis of extracts from HepG2 cells treated with Na2VO3 using Phospho-CBL (Tyr674) antibody P40583.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to CBL (Phospho-Tyr674)

货号：
P40583
别名：
C-CBL; CBL2; Proto-oncogene c-Cbl; RNF55;
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P22681
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to CBL (Phospho-Tyr674)

Description
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.Fernandes MS, et al. (2010) J Biol Chem 285, 32596-605 Teckchandani AM, Panetti TS, Tsygankov AY (2005) Exp Cell Res 307, 247-58

Description

Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.Fernandes MS, et al. (2010) J Biol Chem 285, 32596-605 Teckchandani AM, Panetti TS, Tsygankov AY (2005) Exp Cell Res 307, 247-58

Specification
Aliases	C-CBL; CBL2; Proto-oncogene c-Cbl; RNF55;
Entrez GeneID	867;
Swissprot	P22681
WB Predicted band size	120kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y(p)-S-L) derived from Human CBL.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.