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Rabbit Polyclonal Antibody to PDCD4 (Phospho-Ser67)

Western blot analysis of extracts from HepG2 tissue using Phospho-PDCD4 (Ser67) antibody P40565.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to PDCD4 (Phospho-Ser67)

货号：
P40565
别名：
neoplastic transformation inhibitor;
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q53EL6
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to PDCD4 (Phospho-Ser67)

Description
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNAKakade D, Islam N, Maeda N, Adegoke OA (2014)BMC Cell Biol 15, 2 . Dorrello NV, et al. (2006)Science 314, 467-71. Palamarchuk A, et al. (2005)Cancer Res 65, 11282-6.

Description

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNAKakade D, Islam N, Maeda N, Adegoke OA (2014)BMC Cell Biol 15, 2 . Dorrello NV, et al. (2006)Science 314, 467-71. Palamarchuk A, et al. (2005)Cancer Res 65, 11282-6.

Specification
Aliases	neoplastic transformation inhibitor;
Entrez GeneID	27250;
Swissprot	Q53EL6
WB Predicted band size	56kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of serine 67 (K-N-S(p)-S-R) derived from Human PDCD4 .
Formulation	Purified antibody in PBS with 0.05% sodium azide.