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Western blot analysis of extracts from Jurkat cells treated with PMA using FADD (Phospho-Ser191) Antibody P40519.The lane on the right is treated with the antigen-specific peptide.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody P40519 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to FADD (Phospho-Ser191)

货号：
P40519
别名：
MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity;
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q61160
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to FADD (Phospho-Ser191)

Description
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development

Description

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development

References
Sugano S., Nat. Genet. 36:40-45(2004) Farmer A., Submitted (MAY-2003) Venter J.C., Submitted (JUL-2005).

Specification
Aliases	MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity;
Entrez GeneID	14082;
Swissprot	Q61160
WB Predicted band size	25kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of Serine191(N-M-S(p)-P-V) derived from Mouse FADD.
Formulation	Purified antibody in PBS with 0.05% sodium azide.