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Rabbit Polyclonal Antibody to 4E-BP1 (Phospho-Thr70)

Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using 4E-BP1 (Phospho-Thr70) antibody P40481 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to 4E-BP1 (Phospho-Thr70)

货号：
P40481
别名：
4EBP1; P/OKCL.6; P/OKCL.6; PHAS-I;
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q13541
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to 4E-BP1 (Phospho-Thr70)

Description
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation

Description

4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation

References
Pause A., Nature 371:762-767(1994) Gevaert K., Nat. Biotechnol. 21:566-569(2003) Haghighat A., EMBO J. 14:5701-5709(1995).

Specification
Aliases	4EBP1; P/OKCL.6; P/OKCL.6; PHAS-I;
Entrez GeneID	1978;
Swissprot	Q13541
WB Predicted band size	12kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.