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Immunohistochemical analysis of paraffin-embedded human brain tissue using ITCH (Phospho-Tyr420) antibody P40475 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to ITCH (Phospho-Tyr420)

货号：
P40475
别名：
AIF4; AIP4; NAPP1;
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q96J02
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to ITCH (Phospho-Tyr420)

Description
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.Chen X., Genomics 73:238-241(2001)Deloukas P., Nature 414:865-871(2001)Wood J.D., Mol. Cell. Neurosci. 11:149-160(1998)

Description

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain.Chen X., Genomics 73:238-241(2001)Deloukas P., Nature 414:865-871(2001)Wood J.D., Mol. Cell. Neurosci. 11:149-160(1998)

Specification
Aliases	AIF4; AIP4; NAPP1;
Entrez GeneID	83737;
Swissprot	Q96J02
WB Predicted band size	102kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 420(F-I-Y(p)-G-N) derived from Human ITCH .
Formulation	Purified antibody in PBS with 0.05% sodium azide.