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Rabbit Polyclonal Antibody to Trk A (Phospho-Tyr757)

Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody P40458 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to Trk A (Phospho-Tyr757)

货号：
P40458
别名：
TRKA; TRK; NTRK1; p140-TrkA;
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P04629
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to Trk A (Phospho-Tyr757)

Description
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989)Shelton D.L., J. Neurosci. 15:477-491(1995)The MGC Project Team, Genome Res. 14:2121-2127(2004)

Description

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989)Shelton D.L., J. Neurosci. 15:477-491(1995)The MGC Project Team, Genome Res. 14:2121-2127(2004)

Specification
Aliases	TRKA; TRK; NTRK1; p140-TrkA;
Entrez GeneID	4914;
Swissprot	P04629
WB Predicted band size	87kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.