Rabbit Polyclonal Antibody to PEK/PERK (Phospho-Thr982)

Description
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)

References
Shi Y., An J., J. Biol. Chem. 274:5723-5730(1999) Sood R., Biochem. J. 346:281-293(2000) The MGC Project Team; Genome Res. 14:2121-2127(2004).

Specification
Aliases	E2AK3; PERK; PEK; EIF2AK3;
Entrez GeneID	9451;
Swissprot	Q9NZJ5
WB Predicted band size	125kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine 982(R-H-T(p)-G-Q) derived from Human PEK/PERK.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
IHC	1/50-1/100