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Rabbit Polyclonal Antibody to PAK2 (Phospho-Ser197)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PAK2 (Phospho-Ser197) antibody P40451 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to PAK2 (Phospho-Ser197)

货号：
P40451
别名：
gamma-PAK; PAK65; PAKI; PAK 2;
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q13177
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to PAK2 (Phospho-Ser197)

Description
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.Martin G.A., EMBO J. 14:1970-1978(1995)The MGC Project Team; Genome Res. 14:2121-2127(2004)Olsen J.V., Cell 127:635-648(2006)

Description

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.Martin G.A., EMBO J. 14:1970-1978(1995)The MGC Project Team; Genome Res. 14:2121-2127(2004)Olsen J.V., Cell 127:635-648(2006)

Specification
Aliases	gamma-PAK; PAK65; PAKI; PAK 2;
Entrez GeneID	5062;
Swissprot	Q13177
WB Predicted band size	58kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of Serine 197(T-R-S(p)-V-I) derived from Human PAK2.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.