Rabbit Polyclonal Antibody to LATS1/2 (Phospho-Thr1079/1041)

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Tao W., Nat. Genet. 21:177-181(1999)Nishiyama Y., FEBS Lett. 459:159-165(1999)The MGC Project Team, Genome Res. 14:2121-2127(2004).