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Rabbit Polyclonal Antibody to ABL1 (Phospho-Thr735)
-
货号:
P40429 -
别名:
Abelson murine leukemia viral oncogene 1; ABL1; c-ABL; JTK7; p150 -
应用:
WB -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
P00519 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Rabbit Polyclonal Antibody to ABL1 (Phospho-Thr735)
Description |
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The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. Fainstein E., Oncogene 4:1477-1481(1989)Shtivelman E., Cell 47:277-284(1986)Chissoe S.L., Genomics 27:67-82(1995). |
Specification |
|
---|---|
Aliases | Abelson murine leukemia viral oncogene 1; ABL1; c-ABL; JTK7; p150 |
Entrez GeneID | 25; |
Swissprot | P00519 |
WB Predicted band size | 135kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Peptide sequence around phosphorylation site of threonine735 (S-V-T(p)-L-P) derived from Human ABL1. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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---|---|
WB | 1/500-1/1000 |
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
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