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Rabbit Polyclonal Antibody to p53 (Phospho-Thr387)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Thr387) antibody P40422 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to p53 (Phospho-Thr387)

货号：
P40422
别名：
TP53; tumor protein p53; Tumor suppressor p53;
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P04637
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to p53 (Phospho-Thr387)

Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.Zakut-Houri R., EMBO J. 4:1251-1255(1985)Lamb P., Mol. Cell. Biol. 6:1379-1385(1986)Harlow E., Mol. Cell. Biol. 5:1601-1610(1985)

Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.Zakut-Houri R., EMBO J. 4:1251-1255(1985)Lamb P., Mol. Cell. Biol. 6:1379-1385(1986)Harlow E., Mol. Cell. Biol. 5:1601-1610(1985)

Specification
Aliases	TP53; tumor protein p53; Tumor suppressor p53;
Entrez GeneID	7157;
Swissprot	P04637
WB Predicted band size	43kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine 387(F-K-T(p)-E-G) derived from Human p53.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.