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Western blot analysis of extracts from HepG2 cells using EPHA2/3/4 (Phospho-Tyr588/596) Antibody P40401.The lane on the right is treated with the antigen-specific peptide.

Immunofluorescence staining of methanol-fixed HeLa cells using EPHA2/3/4 (Phospho-Tyr588/596) Antibody P40401.

Rabbit Polyclonal Antibody to EPHA2/3/4 (Phospho-Tyr588/596)

货号：
P40401
别名：
ECK; MPK-5; SEK2; kinase EphA2;
产品上架时间：
2024-01-01
应用：
WB,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P29317
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to EPHA2/3/4 (Phospho-Tyr588/596)

Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990)Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005)Zhuang G., J. Biol. Chem. 282:2683-2694(2007)

Description

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990)Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005)Zhuang G., J. Biol. Chem. 282:2683-2694(2007)

Specification
Aliases	ECK; MPK-5; SEK2; kinase EphA2;
Entrez GeneID	1969;
Swissprot	P29317
WB Predicted band size	130kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.
Formulation	Purified antibody in PBS with 0.05% sodium azide.