提醒成功

QQ登录

微信登录

同意并阅读使用条款和隐私策略

账号密码登录

微信/QQ登录

没有账号？立即注册

搜索

抗体销售咨询健康评估咨询 mRNA-LNP咨询

0731-88388787

首页 > 产品中心 > 产品详情

Western blot analysis of extracts from HUVEC cells treated with PMA using Pim-1 (Phospho-Tyr309) Antibody P40390.The lane on the right is treated with the antigen-specific peptide.

Rabbit Polyclonal Antibody to Pim-1 (Phospho-Tyr309)

货号：
P40390
别名：
PIM-1; Proto-oncogene serine/threonine-protein kinase pim-1; EC 2.7.11.1;
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P11309
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

分享
咨询
收藏

加入购物车

立即购买

Rabbit Polyclonal Antibody to Pim-1 (Phospho-Tyr309)

Description
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.

Description

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.

References
Selten G., Cell 46:603-611(1986) Saris C.J., EMBO J. 10:655-664(1991) Maita H., Eur. J. Biochem. 267:5168-5178(2000).

Specification
Aliases	PIM-1; Proto-oncogene serine/threonine-protein kinase pim-1; EC 2.7.11.1;
Entrez GeneID	5292;
Swissprot	P11309
WB Predicted band size	45kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.