提醒成功

QQ登录

微信登录

同意并阅读使用条款和隐私策略

账号密码登录

微信/QQ登录

没有账号？立即注册

搜索

抗体销售咨询健康评估咨询 mRNA-LNP咨询

0731-88388787

首页 > 产品中心 > 产品详情

Western blot analysis of extracts from HepG2 cells treated with EGF using ACK1 (Phospho-Tyr284) Antibody P40385.The lane on the right is treated with the antigen-specific peptide.

Immunofluorescence staining of methanol-fixed A549 cells using ACK1 (Phospho-Tyr284) Antibody P40385.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ACK1 (Phospho-Tyr284) antibody P40385 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to ACK1 (Phospho-Tyr284)

货号：
P40385
别名：
ACK1; Activated p21cdc42Hs kinase; EC 2.7.10.2; kinase ACK1;
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q07912
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

分享
咨询
收藏

加入购物车

立即购买

Rabbit Polyclonal Antibody to ACK1 (Phospho-Tyr284)

Description
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Manser E., Nature 363:364-367(1993)Ota T., Nat. Genet. 36:40-45(2004)Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Description

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Manser E., Nature 363:364-367(1993)Ota T., Nat. Genet. 36:40-45(2004)Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Specification
Aliases	ACK1; Activated p21cdc42Hs kinase; EC 2.7.10.2; kinase ACK1;
Entrez GeneID	10188;
Swissprot	Q07912
WB Predicted band size	120kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y(p)-V-M) derived from Human ACK1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.