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Western blot analysis of extracts from 293 cells treated with UV using p90 RSK (Phospho-Thr573) Antibody P40381.The lane on the right is treated with the antigen-specific peptide.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p90 RSK (Phospho-Thr573) antibody P40381 (left)or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to p9RSK (Phospho-Thr573)

货号：
P40381
别名：
KS6A1; p90RSK1; RSK1; RPS6KA1;
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q15418
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to p9RSK (Phospho-Thr573)

Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206. Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048. Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835.

Description

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes.Eiichi Takahashi, J. Biol. Chem., Jul 1999; 274: 20206. Ye Zhang, J. Biol. Chem., May 2002; 277: 19042 - 19048. Ganesh R. Panta, Mol. Cell. Biol., Mar 2004; 24: 1823 - 1835.

Specification
Aliases	KS6A1; p90RSK1; RSK1; RPS6KA1;
Entrez GeneID	6195;
Swissprot	Q15418
WB Predicted band size	95kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine 573(L-M-T(p)-P-C) derived from Human p90 RSK.
Formulation	Purified antibody in PBS with 0.05% sodium azide.