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Western blot analysis of extracts from HT29 cells untreated or treated with PMA using FAK(phospho-Tyr576/Tyr577) Antibody P40328.
Immunofluorescence staining of methanol-fixed Hela cells using FAK(phospho-Tyr576/Tyr577) Antibody P40328.
Rabbit Polyclonal Antibody to FAK(phospho-Tyr576/Tyr577)
-
货号：
P40328 -
别名：
FADK 1; FAK1; PTK2 -
应用：
WB,IF -
反应种属：
Human,Mouse,Rat -
抗体类型：
Primary antibody -
Swissprot：
Q05397 -
规格：
-
数量：
-+ -
说明书：
目录价¥2180
Rabbit Polyclonal Antibody to FAK(phospho-Tyr576/Tyr577)
Description |
|---|
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. |
References |
|---|
| Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613 Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. Cobb, B.S. et al. (1994) Mol. Cell. Biol. 14, 147-155. Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334. |
Specification |
|
|---|---|
| Aliases | FADK 1; FAK1; PTK2 |
| Entrez GeneID | 5747; |
| Swissprot | Q05397 |
| WB Predicted band size | 125kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 576/tyrosine 577 (S-T-Y(p)-Y(p)-K-A) derived from Human FAK. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IF/ICC | 1/100-1/200 |
Product Image
For Reseach Only
Application Key：WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
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