Rabbit Polyclonal Antibody to TrkB(Phospho-Tyr515)

Description
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

References
Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.

Specification
Aliases	BDNF/NT-3 growth factors receptor precursor; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; Trk-B
Entrez GeneID	4915;
Swissprot	Q16620
WB Predicted band size	140kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G) derived from Human TrkB.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
IF/ICC	1/100-1/200