Rabbit Polyclonal Antibody to SHP-2(Phospho-Tyr542)

Description
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

References
Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14(9): 3911-3928. Shi ZQ, et al. (2000) Mol Cell Biol. 20(5): 1526-1536. Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96(17): 9677-9682 Manes S, et al. (1999) Mol Cell Biol. 19(4): 3125-3135. Oh ES, et al. (1999) Mol Cell Biol; 19(4): 3205-3215.

Specification
Aliases	PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11
Entrez GeneID	5781;
Swissprot	Q06124
WB Predicted band size	72kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 542 (H-E-Y(p)-T-N) derived from Human SHP-2.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100