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Western blot analysis of extracts from HT29 cells, treated with CA or calf intestinal phosphatase (CIP), using IκB-β (Phospho-Ser23) Antibody P40275.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkB-b(Phospho-Ser23) Antibody P40275(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to IkB-b(Phospho-Ser23)

货号：
P40275
别名：
I-kappa-B-beta; IKB-B; IKBB; NF-kappa-BIB; NF-kappaB inhibitor beta
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q15653
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to IkB-b(Phospho-Ser23)

Description
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Description

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

References
Shirane, M. et al. (1999) J Biol Chem 274, 28169-28174. DiDonato J, et al. (1996) Mol Cell Biol 16(4): 1295-304

Specification
Aliases	I-kappa-B-beta; IKB-B; IKBB; NF-kappa-BIB; NF-kappaB inhibitor beta
Entrez GeneID	4793;
Swissprot	Q15653
WB Predicted band size	48kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of serine 23 (L-G-S(p)-L-G) derived from Human IkB-b.
Formulation	Purified antibody in PBS with 0.05% sodium azide.