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Western blot analysis of extracts from 293 cells untreated or treated with PMA using GSK3α/β(Phospho-Tyr279/216) Antibody P40273.

Immunofluorescence staining of methanol-fixed Hela cells using GSK3α/β(Phospho-Tyr279/216) Antibody P40273.

Immunofluorescence staining of methanol-fixed MEF cells using GSK3α/β(Phospho-Tyr279/216) Antibody P40273.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GSK3α/β(Phospho-Tyr279/216) Antibody P40273 (left) or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to GSK3α/β(Phospho-Tyr279/216)

货号：
P40273
别名：
Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P49840
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to GSK3α/β(Phospho-Tyr279/216)

Description
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Description

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

References
Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222

Specification
Aliases	Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta
Entrez GeneID	2931;
Swissprot	P49840
WB Predicted band size	46, 51kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3α/β.
Formulation	Purified antibody in PBS with 0.05% sodium azide.