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Western blot analysis of extracts from mouse brain tissue using a-Synuclein(Phospho-Tyr136) Antibody P40262 and the same antibody preincubated with blocking peptide.

Immunofluorescence staining of methanol-fixed Hela cells using a-Synuclein(Phospho-Tyr136) Antibody P40262.

Rabbit Polyclonal Antibody to a-Synuclein(Phospho-Tyr136)

货号：
P40262
别名：
NACP; SYN; SYUA
产品上架时间：
2024-01-01
应用：
WB,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P37840
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to a-Synuclein(Phospho-Tyr136)

Description
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Description

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

References
Takahashi T, et al. J Biol Chem 2003 Oct 24; 278(43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277(14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16(2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

Specification
Aliases	NACP; SYN; SYUA
Entrez GeneID	6622;
Swissprot	P37840
WB Predicted band size	18kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 136 (Q-D-Y(p)-E-P) derived from Human a-Synuclein.
Formulation	Purified antibody in PBS with 0.05% sodium azide.