Rabbit Polyclonal Antibody to PKR(Phospho-Thr446)

Description
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

References
Abujiang Pataer, et,al. (2002) Cancer Res; 62: 2239. K. D. Ryman, et,al. (2005) J. Virol; 79: 1487 - 1499. Susana Guerra, et,al. (2006) J. Biol. Chem; 281: 18734 - 18745.

Specification
Aliases	ADRB2; E2AK2; EIF2AK2; EIF2aK; PRKR
Entrez GeneID	5610;
Swissprot	P19525
WB Predicted band size	68kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S) derived from Human PKR.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000