Rabbit Polyclonal Antibody to SAPK/JNK(Phospho-Thr183)

Description
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.

References
Ferrer, et al. (2003) Neuropathology & Applied Neurobiology 29: 23 Zhonghong Guan, et al. (1999) J Biol Chem, Vol. 274: 36200-36206 D.Margriet Ouwens1, et al. (2002)The EMBO Journal 21: 3782

Specification
Aliases	JNK2
Entrez GeneID	5601;
Swissprot	P45984
WB Predicted band size	46 54 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of threonine 183 (M-M-T(p)-P-Y) derived from Human SAPK/JNK.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100