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Western blot analysis of extracts from HT29 cells untreated or treated with Anisomycin using BRCA1(Phospho-Ser1423) Antibody P40226.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BRCA1(Phospho-Ser1423) Antibody P40226(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to BRCA1(Phospho-Ser1423)

货号：
P40226
别名：
RNF53
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P38398
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to BRCA1(Phospho-Ser1423)

Description
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Description

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

References
Kim ST, et al. (2002) Genes Dev; 16(5): 560-570Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002

Specification
Aliases	RNF53
Entrez GeneID	672;
Swissprot	P38398
WB Predicted band size	220kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P) derived from Human BRCA1.
Formulation	Purified antibody in PBS with 0.05% sodium azide.