Rabbit Polyclonal Antibody to IRS-1(Phospho-Ser639)

Description
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

References
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76Steppan CM, et al. (2005) Mol Cell Biol; 25(4): 1569-1575Batty IH, et al. (2004) Biochem J; 379(Pt 3): 641-651

Specification
Aliases	IRS-1; IRS1;
Entrez GeneID	3667;
Swissprot	P35568
WB Predicted band size	180kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of serine 639 (P-K-S(p)-V-S) derived from Human IRS-1.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100