Rabbit Polyclonal Antibody to MEK1/MEK2(Phospho-Ser217/Ser221)

Description
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

References
Shen R, et al. (2002) Mol Cell Biol; 22(10): 3230-3236Preisinger C, et al. (2005) EMBO J; 24(4): 753-765Laine P, et al. (2000) Biochem J; 349(Pt 1): 19-25Yaglom J, et al. (2003) Mol Cell Biol; 23(11): 3813-3824Dahan S, et al. (2002) Infect Immun; 70(5): 2304-2310

Specification
Aliases	ERK activator kinase 1/ERK activator kinase2; MAP kinase kinase 1/MAP kinase kinase 2; MAP2K1/MAP2K1; MAPK/ERK kinase 1/MAPK/ERK kinase 2; MAPKK 1/MAPKK 1
Entrez GeneID	5604;
Swissprot	Q02750
WB Predicted band size	45kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of serine 217/221 (I-D-S(p)-M-A) derived from Human MEK1/MEK2.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100