Rabbit Polyclonal Antibody to Zap-70(Phospho-Tyr493)

Description
Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.

References
Chan AC, et al. (1995) EMBO J; 14(11): 2499-2508Kong G, et al. (1996) Mol Cell Biol; 16(9): 5026-5035Salomon AR, et al. (2003)Proc Natl Acad Sci U S A; 100(2): 443-448

Specification
Aliases	70 kDa zeta-associated protein; SRK; Syk-related tyrosine kinase; ZA70; ZAP-70
Entrez GeneID	7535;
Swissprot	P43403
WB Predicted band size	70kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Peptide sequence around phosphorylation site of tyrosine 493 (S-Y-Y(p)-T-A) derived from Human Zap-70.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000
IHC	1/50-1/100