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Immunofluorescence staining of methanol-fixed Hela cells using HDAC8(Phospho-Ser39) Antibody P40125.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC8(Phospho-Ser39) Antibody P40125(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to HDAC8(Phospho-Ser39)

货号：
P40125
别名：
HD8; HDA8; HDACL1
产品上架时间：
2024-01-01
应用：
IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9BY41
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to HDAC8(Phospho-Ser39)

Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC8 gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

References
Lee H, et al. (2004) Mol Cell Biol. 24(2): 765-773.

Specification
Aliases	HD8; HDA8; HDACL1
Entrez GeneID	55869;
Swissprot	Q9BY41
WB Predicted band size	42kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine 39 (R-A-S(p)-M-V) derived from Human HDAC8.
Formulation	Purified antibody in PBS with 0.05% sodium azide.