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Western blot analysis of extracts from UV-treated C2C12, PMA-treated Hela and anisomycin-treated 293 cells using LIMK1(Phospho-Thr508) Antibody P40123.
Lane 1 : HelaΒ treated with PMA
Lane 2 : Mouse brain tissue
Lane 3 : Rat brain tissue
Lane 4 : N-peptide blocked HelaΒ treated with PMA
Lane 5 : N-peptide blocked Mouse brain tissue
Lane 6 : N-peptide blocked Rat brain tissue
Lane 7 : P-peptide blocked HelaΒ treated with PMA
Lane 8 : P-peptide blocked Mouse brain tissue
Lane 9 : P-peptide blocked Rat brain tissue
Lysates/proteins at 40 μg per lane
Predicted band size :Β 72 kDa
Observed band size :Β 72 kDa
Immunofluorescence staining of methanol-fixed Hela cells using LIMK1(Phospho-Thr508) Antibody P40123.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using LIMK1(Phospho-Thr508) Antibody P40123(left) or the same antibody preincubated with blocking peptide(right).
Rabbit Polyclonal Antibody to LIMK1(Phospho-Thr508)
-
货号：
P40123 -
别名：
LIMK-1; kinase LIMK1; -
应用：
WB,IHC,IF -
反应种属：
Human,Mouse,Rat -
抗体类型：
Primary antibody -
Swissprot：
P53667 -
规格：
-
数量：
-+ -
说明书：
目录价¥2180
Rabbit Polyclonal Antibody to LIMK1(Phospho-Thr508)
Description |
|---|
Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development. |
References |
|---|
| Soosairajah J, et al. (2005) EMBO J. Ohashi K, et al. (2000) J Biol Chem; 275(5): 3577-82. Edwards DC, et al. (1999) Nat Cell Biol; 1(5): 253-9. |
Specification |
|
|---|---|
| Aliases | LIMK-1; kinase LIMK1; |
| Entrez GeneID | 3984; |
| Swissprot | P53667 |
| WB Predicted band size | 72kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of threonine 508 (R-Y-T(p)-V-V) derived from Human LIMK1. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
| IF/ICC | 1/100-1/200 |
Product Image
- Western blot analysis of extracts from UV-treated C2C12, PMA-treated Hela and anisomycin-treated 293 cells using LIMK1(Phospho-Thr508) Antibody P40123.
- Lane 1 : HelaΒ treated with PMA Lane 2 : Mouse brain tissue Lane 3 : Rat brain tissue Lane 4 : N-peptide blocked HelaΒ treated with PMA Lane 5 : N-peptide blocked Mouse brain tissue Lane 6 : N-peptide blocked Rat brain tissue Lane 7 : P-peptide blocked HelaΒ treated with PMA Lane 8 : P-peptide blocked Mouse brain tissue Lane 9 : P-peptide blocked Rat brain tissue Lysates/proteins at 40 μg per lane Predicted band size :Β 72 kDa Observed band size :Β 72 kDa
- Immunofluorescence staining of methanol-fixed Hela cells using LIMK1(Phospho-Thr508) Antibody P40123.
- Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using LIMK1(Phospho-Thr508) Antibody P40123(left) or the same antibody preincubated with blocking peptide(right).
For Reseach Only
Application Key：WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#P40123
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