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Western blot analysis of extracts from Hela cells using p53(Phospho-Ser315) Antibody P40098(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).

Immunofluorescence staining of methanol-fixed Hela cells using p53(Phospho-Ser315) Antibody P40098.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53(Phospho-Ser315) Antibody P40098(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to p53(Phospho-Ser315)

货号：
P40098
别名：
Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P04637
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to p53(Phospho-Ser315)

Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

References
Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-5934.Lohrum, M. et.al. (1996) Oncogene 13, 2527-2539.Posp

Specification
Aliases	Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
Entrez GeneID	7157;
Swissprot	P04637
WB Predicted band size	53kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine 315 (S-S-S(p)-P-Q) derived from Human p53.
Formulation	Purified antibody in PBS with 0.05% sodium azide.