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Rabbit Polyclonal Antibody to p53(Phospho-Ser15)

Western blot analysis of extracts from 293 cells untreated or treated with UV using p53(Phospho-Ser15) Antibody P40092.

Immunofluorescence staining of methanol-fixed Hela cells using p53(Phospho-Ser15) Antibody P40092.

Immunofluorescence staining of methanol-fixed Hela cells using p53 (Phospho-Ser15) Antibody P40092.

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Ser15) Antibody P40092 (left) or the same antibody preincubated with blocking peptide (right).

Rabbit Polyclonal Antibody to p53(Phospho-Ser15)

货号：
P40092
别名：
Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
产品上架时间：
2024-06-05
应用：
WB,IHC,IF,IP
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P04637
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to p53(Phospho-Ser15)

Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

References
Lin T, et al. (2005) Nat Cell Biol; 7(2): 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24(23): 10366-80. Li J, et al. (2004) J Biol Chem; 279(40): 41275-9. Wang J, et al. (2004) J Biol Chem; 279(38): 39584-92.

Specification
Aliases	Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
Entrez GeneID	7157;
Swissprot	P04637
WB Predicted band size	53kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine 15 (P-L-S(p)-Q-E) derived from Human p53.
Formulation	Purified antibody in PBS with 0.05% sodium azide.