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Western blot analysis of TOP1 in Jurkat lysates using Topoisomerase I antibody.

Immunohistochemistry analysis of paraffin-embedded Human colon using TOP1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Rabbit Polyclonal Antibody to Topoisomerase I

货号：
P22840
别名：
TOP1; DNA topoisomerase 1; DNA topoisomerase I
产品上架时间：
2024-01-01
应用：
WB,IHC,IF,FCM
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P11387
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Topoisomerase I

Description
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.

Description

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.

Specification
Aliases	TOP1; DNA topoisomerase 1; DNA topoisomerase I
Entrez GeneID	7150
Swissprot	P11387
WB Predicted band size	Calculated MW: 91 kDa; Observed MW: 91 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	A synthesized peptide derived from human TOP1
Formulation	Purified antibody in PBS with 0.05% sodium azide.