Rabbit Monoclonal Antibody to HMGB1

Description
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription.

Specification
Aliases	HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1
Entrez GeneID	3146
Swissprot	P09429
WB Predicted band size	Calculated MW: 25 kDa; Observed MW: 25 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthetic peptide of human HMGB1
Formulation	Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100