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Immunohistochemical analysis of paraffin-embedded human normal cardiac muscle tissue, showing cytoplasmic localization using cTnI mouse mAb with DAB staining.

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Mouse Monoclonal Antibody to cTnI

货号：
20050
别名：
CMH7; RCM1; cTnI; CMD2A; TNNC1
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P19429
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to cTnI

Description
cTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

Description

cTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

References
1. Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19(10):999-1010. 2. Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113(6):1333-44. 3. Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8. 4. Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29(2):271-8. 5. Adams JE III, Bodor GS, Davila-Roman VG, et al, Circulation, 1993, 88(1):101-6.

References

1. Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19(10):999-1010.
2. Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113(6):1333-44.
3. Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8.
4. Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29(2):271-8.
5. Adams JE III, Bodor GS, Davila-Roman VG, et al, Circulation, 1993, 88(1):101-6.

Specification
Aliases	CMH7; RCM1; cTnI; CMD2A; TNNC1
Entrez GeneID	7137
Swissprot	P19429
clone	3A10A12
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of cTnI expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.