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Mouse Monoclonal Antibody to CD243
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货号:
31568 -
别名:
ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; GP170 -
产品上架时间:
2024-01-01 -
应用:
FCM -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
P08183 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180
Mouse Monoclonal Antibody to CD243
Description |
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. |
References |
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1.Crit Rev Eukaryot Gene Expr. 2017;27(2):173-181. 2.Cancer Chemother Pharmacol. 2017 Jun;79(6):1179-1186. |
Specification |
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Aliases | ABCB1; CLCS; MDR1; P-GP; PGY1; ABC20; GP170 |
Entrez GeneID | 5243 |
Swissprot | P08183 |
clone | 4G6F4 |
WB Predicted band size | 141.1kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human CD243 (AA: 1149-1280) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#31568
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