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EnzymeLinked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phospho-peptide (Phospho-left) and NonPhospho-peptide (Phospho-right), using RBL1 (Phospho-Thr36antibody

Immunohistochemical analysis of paraffin-embedded Human tonsils using Phospho-p107 (Thr369) antibody. Sample with blocking peptide on the right.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Rabbit Polyclonal Antibody to Phospho-p107 (Thr369)

货号：
P20293
别名：
PRB1; p107; CP107
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P28749
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to Phospho-p107 (Thr369)

Description
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Description

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Specification
Aliases	PRB1; p107; CP107
Entrez GeneID	5933
Swissprot	P28749
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	The antiserum was produced against synthesized peptide derived from human RBL1 around the phosphorylation site of Thr369. AA range:335-384
Formulation	Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.