Rabbit Polyclonal Antibody to Phospho-IRE1 (Ser724)

Description
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Specification
Aliases	ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
Entrez GeneID	2081
Swissprot	O75460
WB Predicted band size	Calculated MW: 110 kDa; Observed MW: 110 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human Phospho-IRE1 (S724)
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000