Rabbit Monoclonal Antibody to Phospho-Presenilin 1 (Ser310)

Description
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity.

Specification
Aliases	PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182
Entrez GeneID	5663
Swissprot	P49768
WB Predicted band size	Calculated MW: 53 kDa; Observed MW: 22 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1
Formulation	Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application
WB	1/500-1/1000