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Flow cytometric analysis of hela cells using IKBKE mouse mAb (green) and negative control (red).
Flow cytometric analysis of NH3T3 cells using IKBKE mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded rat kidney tissues using IKBKE mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using IKBKE mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using IKBKE mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded rabbit liver tissues using IKBKE mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded rabbit kidney tissues using IKBKE mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded rabbit lmouse tissues using IKBKE mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissues using IKBKE mouse mAb with DAB staining.
HOT

Mouse Monoclonal Antibody to IKBKE

  • 货号:

    20174
  • 别名:

    IKBKE
  • 产品上架时间:

    2024-03-03
  • 应用:

    FCM,IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q14164
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to IKBKE

Description

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B

References

1. Cell. 2007 Jun 15;129(6):1065-79.
2. Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13.
3. Arthritis Rheum. 2007 Mar;56(3):743-52.

Specification

Aliases IKBKE
Entrez GeneID 9641
Swissprot Q14164
clone 6B4B5
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of IKBKE (aa1-257) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000