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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Immunofluorescence analysis of Hela cells using RUNX3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of Hela cells using RUNX3 mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using RUNX3 mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using RUNX3 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to RUNX3

货号：
31207
别名：
AML2; CBFA3; PEBP2aC
产品上架时间：
2024-01-01
应用：
IHC,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q13761
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to RUNX3

Description
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.

Description

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.

References
1.Genet Mol Res. 2015 Dec 1;14(4):15505-10. 2.J Pathol. 2015 Dec;237(4):520-31.

Specification
Aliases	AML2; CBFA3; PEBP2aC
Entrez GeneID	864
Swissprot	Q13761
clone	7E2B8
WB Predicted band size	44.4kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human RUNX3 (AA: 294-429) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide