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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Immunofluorescence analysis of Hela cells using PRKAG3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Immunohistochemical analysis of paraffin-embedded human rectum tissues using PRKAG3 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to PRKAG3

  • 货号:

    31188
  • 别名:

    AMPKG3
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,ICC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q9UGI9
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

加入购物车

Mouse Monoclonal Antibody to PRKAG3

Description

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.

References

1.Diabetologia. 2010 Sep;53(9):1986-97.
2.PLoS One. 2007 Sep 19;2(9):e903.

Specification

Aliases AMPKG3
Entrez GeneID 53632
Swissprot Q9UGI9
clone 2C7A7
WB Predicted band size 54.3kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human PRKAG3 (AA: 9-151) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
ICC 1/200 - 1/1000
ELISA 1/10000