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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Immunofluorescence analysis of Hela cells using UFD1L mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using UFD1L mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using UFD1L mouse mAb with DAB staining.

Mouse Monoclonal Antibody to UFD1L

货号：
31059
别名：
UFD1
产品上架时间：
2024-01-01
应用：
IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q92890
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to UFD1L

Description
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.

Description

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.

References
1.Proc Natl Acad Sci U S A. 2011 May 31;108(22):9119-24. 2.Cell Biochem Funct. 2003 Sep;21(3):263-7.

Specification
Aliases	UFD1
Entrez GeneID	7353
Swissprot	Q92890
clone	4F11A4
WB Predicted band size	34.5kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human UFD1L (AA: 208-307) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide