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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western blot analysis using CDH11 mouse mAb against MCF-7 (1), Jurkat (2), and HEK293 (3) cell lysate.

Immunofluorescence analysis of HL-7702 cells using CDH11 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of Hela cells using CDH11 mouse mAb (green) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CDH11 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to CDH11

货号：
30999
别名：
OB; CAD11; CDHOB; OSF-4
产品上架时间：
2024-01-01
应用：
WB,IHC,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P55287
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to CDH11

Description
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

Description

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

References
1.Arthritis Rheumatol. 2014 Apr;66(4):1010-21. 2.Mol Cancer Res. 2012 Mar;10(3):293-304.

Specification
Aliases	OB; CAD11; CDHOB; OSF-4
Entrez GeneID	1009
Swissprot	P55287
clone	2C12A6
WB Predicted band size	88kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CDH11 (AA: 468-617) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide