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Mouse Monoclonal Antibody to RAD50
-
货号:
30977 -
别名:
NBSLD; RAD502; hRad50 -
产品上架时间:
2024-01-01 -
应用:
WB,IHC,FCM -
反应种属:
Human,Rat -
抗体类型:
Primary antibody -
Swissprot:
Q92878 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180
Mouse Monoclonal Antibody to RAD50
Description |
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The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
References |
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1.Breast Cancer Res Treat. 2010 Sep;123(2):607-9. 2.Dis Markers. 2008;24(2):127-34. |
Specification |
|
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Aliases | NBSLD; RAD502; hRad50 |
Entrez GeneID | 10111 |
Swissprot | Q92878 |
clone | 3D2G10 |
WB Predicted band size | 154kDa |
Host/Isotype | Mouse IgG2a |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Rat |
Immunogen | Purified recombinant fragment of human RAD50 (AA: 228-359) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
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WB | 1/500 - 1/2000 |
IHC | 1/200 - 1/1000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
- Western blot analysis using RAD50 mouse mAb against C6 (1) and HepG2 (2) cell lysate.
- Flow cytometric analysis of Hela cells using RAD50 mouse mAb (green) and negative control (red).
- Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using RAD50 mouse mAb with DAB staining.
- Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using RAD50 mouse mAb with DAB staining.
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30977
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