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Mouse Monoclonal Antibody to MDM2
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货号:
30749 -
别名:
DMX; hdm2; ACTFS -
产品上架时间:
2024-01-01 -
应用:
FCM -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
Q00987 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180
Mouse Monoclonal Antibody to MDM2
Description |
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This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. |
References |
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Asian Pac J Cancer Prev. 2013;14(3):1925-9. Biomaterials. 2013 Apr;34(11):2738-47. |
Specification |
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Aliases | DMX; hdm2; ACTFS |
Entrez GeneID | 4193 |
Swissprot | Q00987 |
clone | 5A10A9 |
WB Predicted band size | 55.2kDa |
Host/Isotype | Mouse IgG2a |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthesized peptide of human MDM2 (AA: ASEQETLVRPKPLLc). |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
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FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
- Flow cytometric analysis of Hela cells using MDM2 mouse mAb (green) and negative control (red).
- Flow cytometric analysis of Jurkat cells using MDM2 mouse mAb (green) and negative control (red).
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30749
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