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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Flow cytometric analysis of Hela cells using MDM2 mouse mAb (green) and negative control (red).
Flow cytometric analysis of Jurkat cells using MDM2 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to MDM2

  • 货号:

    30749
  • 别名:

    DMX; hdm2; ACTFS
  • 产品上架时间:

    2024-01-01
  • 应用:

    FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q00987
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to MDM2

Description

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

References

Asian Pac J Cancer Prev. 2013;14(3):1925-9.
Biomaterials. 2013 Apr;34(11):2738-47.

Specification

Aliases DMX; hdm2; ACTFS
Entrez GeneID 4193
Swissprot Q00987
clone 5A10A9
WB Predicted band size 55.2kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized peptide of human MDM2 (AA: ASEQETLVRPKPLLc).
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30749