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Mouse Monoclonal Antibody to PKN1
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Mouse Monoclonal Antibody to PKN1
Immunofluorescence analysis of Hela cells using PKN1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Mouse Monoclonal Antibody to PKN1
Flow cytometric analysis of Hela cells using PKN1 mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to PKN1
Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using PKN1 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PKN1
Mouse Monoclonal Antibody to PKN1
Mouse Monoclonal Antibody to PKN1
Mouse Monoclonal Antibody to PKN1

Mouse Monoclonal Antibody to PKN1

  • 货号:

    30717
  • 别名:

    DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q16512
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PKN1

Description

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

References

1. J Biol Chem. 2013 Nov 29;288(48):34658-70.
2. Hum Pathol. 2009 Oct;40(10):1434-40.

Specification

Aliases DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
Entrez GeneID 5585
Swissprot Q16512
clone 4H10B1
WB Predicted band size 104kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human PKN1 (AA: 442-620) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IHC 1/200 - 1/1000
IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000