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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Western blot analysis using SHC1 mouse mAb against NIH/3T3 cell lysate.

Immunofluorescence analysis of A431 cells using SHC1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of NIH/3T3 cells using SHC1 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to SHC1

货号：
30689
别名：
SHC; SHCA
产品上架时间：
2024-01-01
应用：
WB,IF,FCM
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P29353
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to SHC1

Description
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Description

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

References
1. Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H724-32. 2. Clin Cardiol. 2010 Sep;33(9):548-52.

Specification
Aliases	SHC; SHCA
Entrez GeneID	6464
Swissprot	P29353
clone	2F7C7
WB Predicted band size	62.8kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Purified recombinant fragment of human SHC1 (AA: 385-495) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.